News & Events
[VIDEO] Lutter contre les cancers : la mission d’IMSTAR depuis plus de 25 ans !
[VIDEO] Lutter contre les cancers : la mission d’IMSTAR depuis plus de 25 ans ! L’allocution du Président Emmanuel Macron, dans le cadre de la Journée Mondiale Contre [...]
IMSTAR at Carrefour Pathologie, the French leading Pathology congress – November 4-7, 2019, Paris
IMSTAR at Carrefour Pathologie, the French leading Pathology congress - November 4-7, 2019, Paris "Digital quantification of Breast cancer’ Immuno-Histo-Chemistry Markers in daily practice. Evaluation of [...]
IMSTAR innovation developments proof in early cancer assisted detection
IMSTAR innovation developments proof in early cancer assisted detection IMSTAR received a Seal of Excellence from the European Commission, as the institution managing Horizon 2020, the [...]
IMSTAR at the 12th China bioindustry convention, in Guangzhou, June 9 – 12, 2019
IMSTAR AT THE 12th CHINA BIOINDUSTRY CONVENTION, IN GUANGZHOU, JUNE 9 - 12, 2019 The convention is one of the most important events for Bio-Industries in China, [...]
IMSTAR 2019 wishes card
Innovative Cell Reader Analyzer Solution for cost effective tests in Precision Medicine Our mission: Next Generation Cell Imaging software technology for early cancer detection and assistance [...]
IMSTAR will be present at 9th International Capital Conference, Beijing, China
IMSTAR will be present at 9th International Capital Conference, Beijing, China. Françoise Soussaline, IMSTAR President & CEO and Michel Soussaline General Manager, are invited to promote [...]
Scientific Publications
- Socha K., Glaser C., Bienvenu L., Tatarinova E., Papine A., Soussaline F., Soussaline M. Digital quantification of immunohistochemical markers of breast cancer in daily practice. Evaluation of IMSTAR Pathfinder Tumor-Marker Automated Image Analysis System. Pathology Carrefour 2019, Paris, France, November 4-7, 2019. IMSTAR Abstract
- Anderson D., Najafzadeh M., Scally A., Jacob B., Griffith J., Chaha R., Linforth R., Soussaline M., Soussaline F. (2018) Using a Modified Lymphocyte Genome Sensitivity (LGS) test or TumorScan test to detect cancer at an early stage in each individual. The Federation of American Societies for Experimental Biology (FASEB) BioAdvances journal. Anderson_et_al-2019-FASEB_BioAdvances
- Kumar Sharma A., Boberg J., Dybdahl M. (2018) DNA damage in mouse organs and in human sperm cells by bisphenol A. Toxicological & Environmental Chemistry journal (online version https://doi.org/10.1080/02772248.2018.1529236).
- Groult J., Homsy C., Tatarinova E., Da Meda L., Benli-Furet N., Ye F., Papine A., Uzan G., Lebbé C., Wechsler J., Soussaline F. (2018) CTCs/CTMs Automated detection after size-bazed selection from blood of patients with melanoma. 11th International Symposium on Minimal Residual Cancer (ISMRC), Montpellier, France, May 3-5, 2018. PresentationPoster V7-25 juin 18
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Fenech M. (2017) IMSTAR Automated Image Cytometry Micronucleus Scoring systems. HUMN project, Session “Micronuclei and other nuclear anomalies as biomarkers of genotoxicity: mechanisms and application in human in vivo studies’, 12th International Conference on Environmental Mutagenesis (ICEM), Seoul, Korea, November 12-17 th, 2017.
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Dubus J. et al (2017) Medium throughput Comet Assay optimization and development of an automated scoring system. 12th International Comet Assay Workshop (ICAW) Congress, Pamplona, Spain, August 29-31, 2017.
- Alshehe H., Varinot J., Soussaline M., Penna B., Mozer P, Cussenot O., Comperat E.. (2016) Automation of the Gleason Score, The End of the Dilemma. http://www.clinicsinoncology.com cio-v1-id1159 2016-12-06.
- Nersesyan A., Fenech M., Bolognesi C., Misik M., Setayesh T., Wultsch G., Bonassi S., Thomas P., Knasmller S., (2016) Use of the lymphocyte cytokinesis-block micronucleus assay in occupational biomonitoring of genome damage caused by in vivo exposure to chemical genotoxins: Past, present and future. Mutation Research 770 (2016) 1-11.
- Erami K., Sawamoto Y., Yoshino K., Sofuni T., Papine A., Homsy C., Soussaline M., Soussaline F. (2016) Improvement of in situ slide preparation procedure for semi-automated micronucleus counting system. Congress of Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA), Berlin, Germany, October 9-13, 2016.
- Fenech M. (2016) New developments in the lymphocyte cytokinesis-block micronucleus cytome assay high-content, automated analysis, to measure radiation-induced DNA damage.14th International Workshop on Radiation Damage to DNA, Melbourne, Australia, March 20–24th, 2016.
- Soussaline F. (2016) Quantitative Cellular Imaging for Biomarkers Assessment and Validation in Oncology. Sanofi – France R&D Sciences Days 2016 – Innovative Science for patients, Paris, France, March 25, 2016.
- Soussaline F., Quantitative cytogenetics analysis and DNA damage evaluation in human biomonitoring by automated high-throughput high-content Image Cytometry: Pathfinder™ system. In Proceedings of the International symposium on cytogenetic analyses for occupational monitoring, Graz, Southern Austria, September 12th, 2015.
- Gutzkow B.K., Azqueta A., Priestley C., Graupner A., Drlickova M., Dusinska M., Brunborg G., Soussaline F., Collins A., A validation trial- testing genotoxicity of several chemicals using standard, medium- and high-throughput comet formats. In Proceedings of 11th International Comet Assay Workshop (ICAW), Antwerpen, Belgium, September 1-5th, 2015.
- Pourrut B., Ratsizafy I., Hosmy C., Dubus J., Al Souki K., Douay F., Soussaline M., Soussaline F. (2015) Development of an automated scoring system for plant comet assay. In Proceedings of 11th International Comet Assay Workshop (ICAW), Antwerpen, Belgium, September 1-5th, 2015.
- Benzina S., Pitaval A., Lemercier C., Lustremant C., Frouin V., Wu N., Papine A., Soussaline F., Romeo P-H., Gidrol X. (2015) A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation. Cellular and Molecular Life Sciences (The online version of this article (doi: 10.1007/s00018-015-1901-7)
- Jackson P., Pedersen L.M., Kyjovska Z.O., Jacobsen N.R., Vogel U., Wallin H. (2014) Analysis of DNA strand break levels by high-throughput comet assay in frozen tissues. 7 International Nanotoxicology congresses (NanoTox 2014), Antalya, Turkey, April 23-26th, 2014
- Duffy C R.E., Zhang R., How S-E., Lilienkampf A., De Sousa P A., Bradley M. (2014) Long term mesenchymal stem cell culture on a defined synthetic substrate with enzyme free passaging. Biomaterials (The online version of this article http://dx.doi.org/10.1016/j.biomaterials.2014.04.13)
- Ermler, S., Scholze, M. and Kortenkamp, A. (2013) Genotoxic mixtures and dissimilar action: concepts for prediction and assessment, Archives of Toxicology 1- 16.
- Ermler, S., Scholze, M. and Kortenkamp, A. (2013) Seven benzimidazole pesticides combined at sub-threshold levels induce micronuclei in vitro, Mutagenesis 28 (4) : 417- 426.
- Soussaline F. (2013) Lymphocyte Cytokinesis-Block MicroNucleus Cytome assay Automation by Image Cytometry. Oral presentation in the Lymphocyte micronucleus and buccal micronucleus cytome assays for Human and Environmental Monitoring HUMN and HUMNxl Workshop, ULBRA Porto Alegre, Brazil, November 11-14, 2013.
- Soussaline F., Decordier I., Papine A., Vande Look K., Plas G., Tatarinova E., Kirsch-Volders M. (2013) Automated image analysis of the human micronucleus cytome assay for high throughput biomonitoring and in vitro genotoxicity studies: IMSTAR system. In Proceedings of 11th International Conference on Environmental Mutagens (ICEM), Foz do Iguassu, Brazil, November 3-8, 2013.
- Soussaline F., Dumont J., Papine A., Tatarinova E., Lorge E. (2013) Validation of a new scoring method of micronucleated L5178Y cells by high throughput automated image analysis. In Proceedings and oral presentation as short talk in the Symposium “Mechanisms of micronucleus formation by environmental and genetic factors”, chaired by Pr Michael Fenech, of 11th International Conference on Environmental Mutagens (ICEM), Foz do Iguassu, Brazil, November 3-8, 2013.
- Machado MS., Zago LA., Villela IV., Homsy C., Papine A., Soussaline F., Henriques JAP. (2013) Comparative study of manual and Pathfinder automated analysis in GLP cytokinesis-block micronucleus assay. In Proceedings of 11th International Conference on Environmental Mutagens (ICEM), Foz do Iguassu, Brazil, November 3-8, 2013.
- Jackson P., Pedersen L.M., Kyjovska Z.O., Jacobsen N.R., Saber A.T., Hougaard K.S., Vogel U., Wallin H. (2013) Validation of freezing tissues and cells for analysis of DNA stand break levels by comet assay. Mutagenesis vol. 28 no. 6 PP; 699-707.
- Soussaline F., Dumont J., Papine A., Tatarinova E., Lorge E. (2013) Validation of a new scoring method of micronucleated L5178Y cells by high throughput automated image analysis. In Proceedings of German-French DNA Repair Meeting, Illkirch, France, October 7-10, 2013.
- Jackson P. (2013) High-throughput comet analysis with fully automated scoring, using frozen samples. Presentation in the session of 10th International Comet Assay Workshop (ICAW), Porto, Portugal, September 18-20th, 2013.
- Azqueta A., Lopez de Cerain A., Collins A. (2013) Increasing the sensitivity of the comet assay as a genotoxicity assay. Poster Minitalks presented in the session of 10th International Comet Assay Workshop (ICAW), Porto, Portugal, September 18-20th, 2013.
- Dahl H., Graupner A., Gutzkow K. B., Brunborg G. (2013) Automated Scoring of Minigels in a 96 Format. Poster Minitalks presented in the session of 10th International Comet Assay Workshop (ICAW), Porto, Portugal, September 18-20th, 2013.
- Azqueta A., Sanchez O., Lopez de Cerain A. (2013) Do we really need the lysis step in the standard comet assay? Poster Minitalks presented in the session of 10th International Comet Assay Workshop (ICAW), Porto, Portugal, September 18-20th, 2013.
- Kumar Sharma A., Soussaline F., Sallette J. Jørgensen V., Homy C., Dybdahl M. (2013) The influence of the number of cells scored on the sensitivity in the comet assay. Poster Minitalks presented in the session of 10th International Comet Assay Workshop (ICAW), Porto, Portugal, September 18-20th, 2013.
- Fenech M., Kirsch-Volders M., Rossnerova A., Sram R., Romm H., Bolognesi C., Ramakumar A., Soussaline F., Schunck C., Elhajouji A., Anwar W., Bonassi S. (2013) HUMN project initiative and review of validation, quality control and prospects for further development of automated micronucleus assays using image cytometry systems. International Journal of Hygiene and Environmental Health 216 (2013) 541-552.
- Hansen A., Corless S., Cleland A., Petrik J., Gilbert N., Bradley M. (2013) Polymers for the Cell-Specific Immobilisation of Megakaryocytic Cell Lines. Macromolecular Bioscience 2013, 13, 437-443.
- Kumar Sharma A., Soussaline F., Sallette J. Dybdahl M. (2012). The influence of the number of cells scored on the sensitivity in the comet assay. Mutation Research: Genetic Toxicology and Environmental Mutagenesis 749 (2012) 70-75.
- Soussaline F., Decordier I., Papine A., Tatarinova E., Dumont J., Lorge E., Kirsch-Volders M. (2012) Automated image analysis of the micronucleus cytome assay for high throughput human biomonitoring and in vitro genotoxicity studies: IMSTAR system. In Proceedings of 42nd EEMS annual conference, Warsaw, Poland, September 16-20, 2012.
- Ermler S., Scholze M., Kortenkamp A., Project T10022: The combined effects of aneugenic benzimidazoles and other aneugens which act by disrupting microtubuli assembly. Food Standards Agency, Final report, May 2012. (https://www.food.gov.uk/sites/default/files/816-1-1490 FS231023 T10022 Final Report ACCEPTED.pdf)
- Soussaline F. (2012) Criteria for automated image cytometry micronucleus scoring systems evaluation and comparison. Human Workshop: HUMN/HUMNxl Automated Micronucleus Workshop using Image Cytometry Systems, Doha, Qatar, March 26, 2012.
- Kirsch-Volders M., Papine A., Soussaline F., Decordier I. (2012) Automated image analysis of the human micronucleus cytome assay for high throughput biomonitoring studies: IMSTAR system. Human Workshop: HUMN/HUMNxl Automated Micronucleus Workshop using Image Cytometry Systems, Doha, Qatar, March 26, 2012.
- Soussaline F., Papine A., Tatarinova E., Decordier I., Dumont J., Azqueta-Oscoz A., Sharma A.K., Binderup M-L., Collins A., Lorge E., Kirsch-Volders M. (2012) Automated image analysis of the micronucleus cytome assay and comet assay for high throughput human biomonitoring and in vitro/in vivo genotoxicity testing in industry studies: IMSTAR system. In Proceedings of 6th International Conference on Environmental Mutagens in Human Populations, Doha, Qatar, March 26-29, 2012
- Marin-Kuan M., Holzwarth J.A., Fuerholz A., Bezençon CI., Verguet CI., Piguet D., Guignard G., Mansourian R., Raymond F., Metairon S., Schilter B. (2012) Toxicological perspective of Nrf2 activation. In Proceedings of 51st Annual Meeting Society of Toxicology, San Francisco, USA, March 11-15, 2012.
- Azqueta A., Meier S., Priestley C., Bjerve Gutzkow K., Brunborg G., Sallette J., Soussaline F., Collins A. (2011) The influence of scoring method on variability in results obtained with the comet assay. Mutagenesis, vol. 26 (3) pp. 393-399.
- Decordier I., Papine A., Van de Look K., Plas G., Soussaline F., Kirsch-Volders M. (2011) Automated image analysis of micronuclei by IMSTAR for biomonitoring. Mutagenesis, vol. 26 (1) pp. 163-168.
- Gidrol X., Haydont V., Papine A., Soussaline F., Angulo J., Meyer F., Stawiaski J., Cancel-Tassin G., Cussenot O., Frandsen M-N., Lajaunie C., Rouillier P., Vert J-P. (2010) Large scale siRNA and LNA screens identifies kinase & miRNA regulating the differentiation/proliferation balance in prostate cancer cells. In proceedings of “System biology approaches to cancer and metabolic diseases”, Day of Molecular Medicine, Stockholm, Sweden, May 20-22, 2010.
- Emery S., Ouédraogo G., Tatarinova E., Sallette J., Soussaline F., Meunier J-R. (2010) Towards an automated scoring system for the Syrian hamster embryo assay. In Proceedings of the Society of Toxicology’s 49th Annual Meeting and ToxExpoT, Salt Lake City, Utah, USA, March 7-11, 2010.
- Gidrol X., Haydont V., Papine A., Soussaline F., Angulo J., Meyer F., Stawiaski J., Lajaunie C., Rouillier P., Vert J.P (2010) Kinome-targeted siRNA screen identifies, kinase regulating the differentiation/proliferation balance in prostate cancer cells. In Proceedings of TOPIM (hot TOPics in Molecular Imaging) Workshop, Bardonecchia, Italy, February 7-12, 2010.